Filtration though a hydrophilic membrane with 1 micron (1.0 µm) or 0.22 micron (0.22 µm) pores is an important post-processing step of ultrasonic nano-emulsification with NanoStabilizer®-LSO and NanoStabilizer®-LT, which removes such particulate contamination as dust, large microorganisms, plant matter and titanium particles. Syringe filters are single-use and can typically handle 10 - 30 milliliters of product before having to be discarded and replaced. They are typically used when working with the LSP-600 processor configured in the batch mode. There are 20 syringes (30 ml) and 100 filters included in this kit.
Lead time: 1 week.
- Remove particulate contaminants (dust, large microorganisms, plant matter, titanium particles) from nanoemulsions.
- Filter nanoemulsions without rejecting any of the bioactive-containing oil droplets.
- Achieve higher product purity by eliminating particulate contamination.
After the nano-emulsification process is completed, draw up to 30 ml of the product into a syringe and pass it through the filter into an autoclaved dark-glass container.
NanoStabilizer®-LT and LSO User Guides are available for download at our Knowledge Hub.
Q1. Do my nanoemulsion particle sizes change after filtration?
No. Filtration though a hydrophilic membrane with 0.22 micron or 1 micron pores does not change particle sizes in correctly prepared nanoemulsions.
Q2. What about my extract? Could it inadvertently get filtered out?
No. Syringe filters with 0.22 micron or 1 micron pores do not remove any active ingredients, extracts, excipients, carrier oils, preservatives or other formulation components from nanoemulsions in which all droplets are smaller than the corresponding filter pore size (0.22 micron for nanoemulsions made with NanoStabilizer®-LT and 1 micron for nanoemulsions made with NanoStabilizer®-LSO). The hydrophilic character of the filter membrane ensures that the hydrophobic oil droplets have low affinity for the membrane material and will not stick to it as long as they can fit through the pores.
Q3. Will the titanium particles shed by the horn get filtered out?
Yes. Practically all titanium particles shed by the horn are easily removed by filtration. The graph below shows the size distribution of these particles determined by Laser Diffraction (Mictrotrac Analyzer S3500). Since all particles in the distribution are larger than 890 nm, passing the nanoemulsion through a filter with 1 micron pores removes practically all of the titanium. This was was confirmed by ultra sensitive measurements by Inductively Coupled Plasma Mass Spectrometry (Agilent ICP-MS 7500).
Q4 Do I need to filter my nanoemulsion even if there is no visible titanium contamination?
Yes. Filtering your finished nanoemulsion is important, not only for removing titanium particles, but also to remove any other particulates, such as dust, large microorganisms and plant matter.
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